WebThe nucleoside analogue 4-thiothymidine has shown great potential in vitro as a photosensitiser for the photodynamic therapy of numerous cancer cell lines. However, the limited penetrating power of UV-A radiation, to which it responds, raises doubts as to its practical usefulness in clinical applications. WebAt pH 7.5, 4-thiouridine has an absorbance maximum at 330 nm, and the difference in extinction coefficient (Δε) between 4-thiouridine and 4-thiouracil is 3000 М –1 cm –1. 4-Thiouridine proved to be a good substrate for UP: the Michaelis ( К М) and catalytic ( k cat) constants were estimated respectively at 130 μM and 49 s –1 at 25°C.
Interim 4′-[methyl-11C]-thiothymidine PET for predicting the ...
WebSep 17, 2007 · Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status Molecular Cancer Therapeutics American Association for Cancer Research Research Articles: Therapeutics, Targets, and Development September 17 2007 WebJan 3, 2024 · Thio-substituted nucleobases have received long-standing interest from experimental and theoretical scientists due to their potential applications in photodynamic therapy and crosslinking studies. Though the thymidine:4-thiothymidine dimer is an important structure in the DNA duplex, the molecular-level photoreaction mechanisms are … sti computer school tanay
Conformation of sister chromatids in the replicated human genome
WebMar 5, 2015 · 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) has been used to evaluate tumor malignancy and cell proliferation in human brain gliomas. However, 18F-FLT has several limitations in clinical use. Recently, 11C-labeled thymidine analogue, 4′-[methyl-11C]thiothymidine (11C-4DST), became available as an in vivo cell proliferation positron … WebAbstract. Excited-state dynamics of 4-thiothymidine (S 4 -TdR) and its photosensitization to molecular oxygen in solution with UVA irradiation were investigated. Absorption and … WebAbstract. The new substrates 4-thiouridine and 4-thiothymidine were proposed for spectrophotometric measurement of the activity of uridine (UP) and thymidine (TP) … sticting used on pillows