WebChloral hydrate is widely used as a sedative and a hypnotic in pediatric medicine. It is also a byproduct of water chlorination. Chloral hydrate has been shown to be genotoxic in numerous prokaryotic and eukaryotic assay systems including human lymphocytes in vitro. One of its metabolites, trichloro … WebCategories 2 and 3 contain 43 emerging DBPs that are present at moderate levels (sub- to low-μg/L): category 2 contains 29 of these that are genotoxic (including chloral hydrate …
Assessing the genotoxicity of two commonly occurring …
WebJan 1, 2024 · Chloral hydrate (CH) and bromal hydrate (BH) are two trihaloacetaldehydes commonly detected in disinfected waters, but little is known about their genotoxicity, especially BH. We investigated the genotoxicity of CH and BH using a test battery that includes three in vitro genotoxicity assays. WebIts major metabolite, chloral hydrate, widely used as a sedative in both adults and children, is in danger of being banned by comparable studies. This paper assesses the safety of chloral hydrate. Design: Analysis of the literature regarding the metabolic, toxicologic, and epidemiologic data on trichloroethylene and chloral hydrate. headworks bio inc
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, …
WebJul 1, 2024 · Formaldehyde, Acetaldehyde, Chloroacetaldehyde, Dichloroacetaldehyde, Bromochloroacetaldehyde, Trichloroacetaldehyde (chloral hydrate), Tribromoacetaldehyde: ... and chloral hydrate, only chloroacetonitrile and chloral hydrate were not genotoxic. Chloral hydrate has proven to be non-mutagenic in a recent study, whereas its … WebOct 1, 2024 · The lack of genotoxicity observed for 2-chloroethanol in the in vitro experiments adds further support to the historical data indicating that 2-chloroethanol is … WebSep 1, 1993 · Its major metabolite, chloral hydrate, widely used as a sedative in both adults and children, is in danger of being banned by comparable studies. This paper assesses the safety of chloral hydrate. Design. Analysis of the literature regarding the metabolic, toxicologic, and epidemiologic data on trichloroethylene and chloral hydrate. golf cart leaf spring shackle